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They do this by administering drugs that stop the pituitary glands from producing the hormones that trigger puberty. Gillian Wilson , University of Glasgow. We found that mice that do not have ACKR2 start puberty early because the macrophage cells arrive in the breasts prematurely. In the US, it is believed to be happening a full year earlier than a few decades ago. Studies show correlations with depression and eating disorders ; and early developers tend to be tall for their age but actually shorter as adults. The bad news is that throughout the world, puberty is beginning earlier and earlier. The next step is to carry out studies in human patients to find out whether pre-pubertal girls with low levels of ACKR2 go on to develop breasts early.

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