The glands in the breast do secrete fluid also in nonlactating women. In general most mammals develop mammary glands in pairs along these lines, with a number approximating the number of young typically birthed at a time. In this combined control from ECM and systemic hormones, milk secretion can be reciprocally amplified so as to provide enough nutrition for the baby. Ductal development decreases with the arrival of sexual maturity and undergoes estrous cycles proestrus, estrus, metestrus, and diestrus. Terminal end buds, the highly proliferative structures found at the tips of the invading ducts, expand and increase greatly during this stage. Progress in Biophysics and Molecular Biology. During puberty , tubule formation is coupled with branching morphogenesis which establishes the basic arboreal network of ducts emanating from the nipple.
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